Quinolone antibiotics and Iron preparations
Posted on September 1, 2009
Some preliminary evidence shows that iron preparations can reduce the absorption of cipro and ofloxacin front the gut. The auinolone-iron complexes formed have reduced antibacterial effects.
Clinical evidence
A cross-over trial in 12 normal subjects given single doses of 500 mg cipro or 400 mg ofloxacin showed that the concurrent use of 200 mg iron (in the form of an rron-glycine-sulphate complex) reduced the bioavailability of the cipro by 48% and that of ofloxacin by 36%. Another study found that 325 mg ferrous sulphate three times a day reduced the absorption of cipro in normal subjects by 65%. Reduced serum levels of cipro (peak levels reduced from 5 2 to 0.3-0.5) were recorded in another patient while taking ferrous sulphate.
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Tags: Antibiotics, cipro
