Amikacin is a semi-synthetic descendant of kanamycin. Amikacin is an antibiotic which has a brand name amikin. Aminoglycoside is used to treat bacterial infections.
Mechanism of action(MOA)
They cause the blocking mechanism where amino glycoside and cytoplasmic membrane cannot be transported. They freeze the starting of protein synthesis, when they are in the cell. After the exposure to aminoglycosides the amino acids, proteins and sensitive bacteria become permeable and leak out after cell death.
Uses of Amikacin
Hospital acquired infections
It is also used for treating fever and neutropenia when combined with beta lactam antibiotic.
For treating respiratory diseases the liposomal amikacin for inhalation purposes is in clinical trials for pseudomonas, cystic fibrosis, and bronchiectasis.
Some multi drug resistant bacteria like enterobacter, acinobacter, providencia stuartii and pseudomonas aeruginosa.
Dosage and Administration
Dosage should be calculated according to the body weight and renal function level.
For an adult average dose with normal renal levels is CLcr >70 ml/min is amikacin 7.5-1.5 mg/kg/day.
As the half life of amikacin is very short it is given in every 8 hour. The doses are equally divided and injected i.m. However do consult your doctor and ask for a single dose if possible.
Common side-effects are:
- Blurred vision
- Black tarry stools
- Bluish skin
- Bloody urine
- Tingling feeling
- Difficulty in moving
- Difficulty in breathing
- Fullness in ear
- Dry mouth
- Burning sensation
- Decreased urine output .
- Hearing loss
- Muscle pain
- Painful urination
- Pain in joints
- Loss of balance
- Sore throat
- Swelling in glands
- Shortness of breath
Precaution and warning
Give your full personal and family history to the doctor. If you have any allergy to any medication please let your doctor know. This medication may contain inactive ingredients which may cause some harmful effects. If you have any history of hearing, cystic disease or myasthenia gravis, then you should not use this medication before consulting your doctor. While using amikacin, avoid use of any vaccines or immunization as it does not work with vaccines.
Pregnancy and Breast-Feeding
During pregnancy or planning to get pregnant the patient should consult the doctor before using this medication. It has been relatively safe considering other drugs that may harm the fetus. Therefore, women can use it in pregnancy.
While during nursing it does get secrete into milk in small doses. Please get approval of your doctor before using it.
Some drugs like amphotericin B, tobramycin, cisplastin, cephalosporins and ibuprofen. These drugs should never be combined or taken while taking Amikacin. As some drugs may change the course of medications and how they work.
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